For the fourth time, RNID and Fondation Pour l’Audition (FPA) are partnering to co-fund translational research. The RNID-FPA Translational Grant aims to support and accelerate the translation of research discoveries into potential new treatments to protect and regenerate hearing and/or silence tinnitus. It funds projects at both academic institutions and small/medium enterprises in any country.
Why supporting the development of treatments for hearing loss and tinnitus is important
There are almost half a billion people in the world with disabling hearing loss and 1.1 billion young people (aged between 12 to 35 years old) are at risk of losing their hearing due to recreational noise (WHO, 2018).
The evidence for the link between hearing loss and debilitating conditions like dementia is strengthening (Livingston, G et al (2017) The Lancet).
In the UK, around 1 in 8 people has tinnitus. However, there are currently no registered treatments that protect and/or restore hearing or silence tinnitus.
We request translational research proposals that will advance the development of small molecule, gene or cell-based therapeutics for the treatment of hearing disorders, including tinnitus.
We want to support:
- research with a strong commercial potential that is likely to attract follow-on funding at the conclusion of the grant
- studies that will facilitate and enable the progression of promising basic research towards testing in clinical trials.
Summary of grant
- Duration: up to 3 years
- Eligibility: applicants may be from any country and may be from academic institutions and small/medium enterprises (SMEs)
- Value: up to £100,000 per year (note that as a charity, it is our policy not to fund any indirect costs or the salaries of permanent employees)
- Expression of Interest deadline: Friday 8 April 2022 (5pm GMT)
- Full application deadline (by invitation only): Friday 10 June 2022 (5pm GMT)
- Funding decision: December 2022
In the last round of funding, we received 16 Expressions of Interest. 8 applicants were invited to submit a full application and 2 grants were awarded.
Applications can include:
- Studies which will enable lead optimisation and/or candidate selection.
- Pharmacokinetics/Pharmacodynamics (PKPD) studies.
- Safety/toxicology studies.
- Drug repositioning/repurposing (applications must contain preliminary data supporting the proposed approach)
- Validation of therapeutic targets for the treatment of hearing loss or tinnitus (applications must contain preliminary data supporting the proposed approach).
- Studies to strengthen confidence that a target or therapeutic approach will be applicable to human hearing loss or tinnitus.
- Identification/validation of methods or outcomes that could be used for one or more of the following: Patient selection/stratification for clinical trials; Robust measurement of treatment responses in clinical trials.
These studies must support the development of a specific therapeutic. General research into outcome measures not aligned to a specific therapeutic should be submitted to other grant schemes offered by RNID (for example Discovery Research Grant) and Fondation Pour l’ Audition.
Applications will not be accepted in the following areas:
- Basic research into the causes and underpinning biology of hearing loss and tinnitus.
- The development of devices or software.
- The optimization of current clinical protocols.
- Health service studies.
This grant application will follow a two-stage process:
- Expression of interest: all applicants must submit an Expression of Interest. The purpose of the Expression of Interest is to obtain enough information on the proposed project to enable us to understand how well the proposal aligns with the criteria of the Translational Grant scheme. Applicants with proposals meeting the criteria of the Translational Grant scheme will be invited to submit a full application.
- Full application: all applications that successfully complete the Expression of Interest stage will be invited to submit a full application.
In order to protect the confidentiality of the information shared with us by the applicants everyone involved in the review process of any Translational grant application is asked to abide by our code of conduct and to sign a Reviewer Agreement with confidentiality clauses.
Stages of the application procedure
1. Expression of Interest
Expressions of interest are open entry.
Additional information may be requested in order to determine if applications meet the criteria of the scheme.
3. Full application
Full application (by invitation only), following the successful outcome of the Expression of Interest stage.
4. External assessment
All full applications are sent for external peer review by 2 to 3 experts in the field, who are asked to rate the scientific value, feasibility and translational potential of the project. Applicants will have the opportunity to respond to the reviewer’s feedback.
5. Review panel assessment
Full applications, expert reviews and applicant responses are considered by the RNID-FPA Translational Grant Panel who evaluates the proposals’ scientific approach, as well as their commercial and/or translational potential.
Projects are ranked competitively and funding is awarded to the top-rated projects.
How to apply
Use the form below to submit your Expression of Interest.
Applicants whose proposals meet the scheme’s criteria will be invited to submit a full application. We encourage you to read the following documents before you apply:
- Full application form
- 2022 Translational Grant call and guidelines
- Guidance for completing the full application form
A reminder that these studies must support the development of a specific therapeutic. General research into outcome measures not aligned to a specific therapeutic should be submitted to other grant schemes offered by RNID (for example Discovery Research Grant) and Fondation Pour l’ Audition.
- Prof Karen Avraham – Tel Aviv University (FPA Scientific Committee)
- Dr Anna Kenyon – Lived Experience
- Dr Michael Kyriakides – Syncona Investment Management Ltd
- Prof Frank Lin – Johns Hopkins (FPA Scientific Committee)
- Prof Lawrence Lustig – Columbia University (FPA Scientific Committee)
- Dr Klaus Mendla – Auditus Business Consulting
- Mr Peter Monksfield – University Hospitals Birmingham
- Dr Trevor Perrior – Drug Discovery Consultant
- Prof Marcelo Rivolta – Sheffield University
Additional panel members may be recruited.
Project management and reporting
Successful RNID-FPA Translational Grants require annual scientific and financial reporting. This ensures that the milestones are met and the project is successfully completed.
Europe PubMed Central (Europe PMC) and open access publications
RNID is a member of the Europe PMC Funders’ Group. We support open access publications and require RNID grant holders to make their publications open access.
For more information
If you would like more information about the Translational Research grant, contact us.
If you have any questions or need more information, you can contact us. We’re here to help.