University College London
Eleanor Brown is a PhD student in Professor Dan Jagger’s lab at the UCL Ear Institute. RNID is funding her research project investigating sensory loss in Neurofibromatosis Type 2 (NF2) in partnership with the Anatomical Society.
Her project aims to deepen our understanding of this rare genetic disorder, in which non-cancerous tumours grow in the nervous system, particularly along the vestibular and cochlear nerves (which carry information about balance and sound to the brain). These tumours can cause hearing loss, tinnitus, balance issues, and potential sight difficulties.
She completed her undergraduate degree in Biology at the University of Kent in 2022 and completed a summer placement within Dan’s lab that same year.
Eleanor’s current PhD project focuses on identifying the disease processes involved in NF2, particularly their effects on the inner ear. By exploring these processes, she hopes to contribute to the development of targeted treatments for NF2.
Improving our understanding of sensory loss in neurofibromatosis type 2
Read about Eleanor’s research projectEleanor’s approaches to hearing research
There is currently no cure for NF2 and existing treatment options often fall short in effectively managing vestibular schwannomas (tumours on the hearing and balance nerves) and preventing further hearing loss. My research aims to provide a deeper understanding of the microscopic processes underlying hearing loss in NF2. This knowledge could pave the way for the development of targeted therapies, ultimately enhancing affected people’s quality of life.
The studentship has provided me with the opportunity to continue my research at the Ear Institute. I find the environment to be truly inspiring and conducive to my work. The generous funding to focus on NF2 research holds significant personal value for me. Not only does it enable me to contribute to the study of hearing loss, but it also serves as a meaningful platform for networking and collaboration throughout my academic pursuits.
In the realm of research, public involvement and patient engagement are vital components in shaping impactful research, particularly in fields heavily reliant on animal models, such as hearing research. Real-life experiences shared by those with hearing loss show just how important research into the field is and provides a great perspective on why attention is needed to provide potential treatments.